Phenotypic and transcriptional analysis of the osmotic regulator OmpR in Yersinia pestis

ABSTRACT: Background The osmotic regulator OmpR in Escherichia coli regulates differentially the expression of major porin proteins OmpF and OmpC. In Yersinia enterocolitica and Y. pseudotuberculosis, OmpR is required for both virulence and survival within macrophages. However, the phenotypic and regulatory roles of OmpR in Y. pestis are not yet fully understood. Results Y. pestis OmpR is involved in building resistance against phagocytosis and controls the adaptation to various stressful conditions met in macrophages. The ompR mutation likely did not affect the virulence of Y. pestis strain 201 that was a human-avirulent enzootic strain. The microarray-based comparative transcriptome analysis disclosed a set of 224 genes whose expressions were affected by the ompR mutation, indicating the global r

ORGANISM(S): Yersinia pestis

SUBMITTER: Dongsheng Zhou 

PROVIDER: E-GEOD-26601 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress