Gene Expression Changes Associated with the Progression of Intraductal Papillary Mucinous Neoplasms

ABSTRACT: Purpose: The diagnosis of high grade intraductal papillary mucinous neoplasm (IPMN) is difficult to distinguish from low grade IPMN. The aim of this study was to identify potential markers for the discrimination of high grade and invasive IPMN from low and moderate grade IPMN. Experimental Design: Laser capture microdissection was used to isolate distinct foci of low grade, moderate grade, high grade, and invasive IPMN from paraffin embedded archival tissue from 14 patients who underwent resection for IPMN. Most samples included multiple grades in the same specimen. Affymetrix Human Exon microarrays were used for gene expression analysis to compare low and moderate grade (LMD) IPMN to high grade and invasive (HgInv) IPMN. Results: When comparing samples of LMD dysplasia (n=15) to those dem

ORGANISM(S): Homo sapiens

SUBMITTER: Bryan Thibodeau 

PROVIDER: E-GEOD-26647 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress