Impact of exercise training on endothelial transcriptional profiles in healthy swine: A genome-wide microarray analysis

ABSTRACT: While the salutary effects of exercise training on conduit artery endothelial cells have been reported in animals and humans with cardiovascular risk factors or disease, whether a healthy endothelium is alterable with exercise training is less certain. The purpose of this study was to evaluate the impact of exercise training on transcriptional profiles in normal endothelial cells using a genome-wide microarray analysis. Brachial and internal mammary endothelial gene expression was compared between a group of healthy pigs that exercise-trained for 16-20 weeks (n=8) and a group that remained sedentary (n=8). We found that a total of 130 genes were up regulated and 84 genes down regulated in brachial artery endothelial cells with exercise training. In contrast, a total of 113 genes were u

ORGANISM(S): Sus scrofa

SUBMITTER: J Davis 

PROVIDER: E-GEOD-26663 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress