Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Patrick Leahy
PROVIDER: E-GEOD-26727 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Immunity 20110512 5
Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vivo. Exposure of myeloid cells to hypoxia and/or bacterial products reduced KLF2 expression while inducing hypoxia inducible factor-1α (HIF-1α), findings that were recapitulated in human septic pa ...[more]