Comparative genomics and transcriptomics of Propionibacterium acnes

ABSTRACT: The anaerobic Gram-positive bacterium Propionibacterium acnes is a human skin commensal, but is occasionally associated with inflammatory diseases. Recent work has indicated that evolutionary distinct lineages of P. acnes play etiologic roles in disease while others are associated with health. To shed light on the molecular basis for differential strain properties, we carried out genomic and transcriptomic analysis of distinct P. acnes strains. We sequenced the genome of the P. acnes strain 266, a type I-1a sequence type (ST) 18 strain. Comparative genome analysis of strain 266 and four other P. acnes strains revealed that overall genome plasticity is relatively low; however, a number of island-like genomic regions, encoding a variety of putative virulence-associated and fitness traits, di

ORGANISM(S): Propionibacterium acnes

SUBMITTER: Hans-Joachim Mollenkopf 

PROVIDER: E-GEOD-26738 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress