MicroRNA expression profiling of quiescent and activated muscle stem cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Thomas Rando
PROVIDER: E-GEOD-26780 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Maintenance of muscle stem-cell quiescence by microRNA-489.
Cheung Tom H TH Quach Navaline L NL Charville Gregory W GW Liu Ling L Park Lidia L Edalati Abdolhossein A Yoo Bryan B Hoang Phuong P Rando Thomas A TA
Nature 20120223 7386
Among the key properties that distinguish adult mammalian stem cells from their more differentiated progeny is the ability of stem cells to remain in a quiescent state for prolonged periods of time. However, the molecular pathways for the maintenance of stem-cell quiescence remain elusive. Here we use adult mouse muscle stem cells (satellite cells) as a model system and show that the microRNA (miRNA) pathway is essential for the maintenance of the quiescent state. Satellite cells that lack a fun ...[more]
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