Genome-wide binding of Ubx and Hth in 3rd thoracic imaginal discs

ABSTRACT: The Hox genes are responsible for generating morphological diversity along the anterior-posterior axis during animal development. The Drosophila Hox gene Ultrabithorax (Ubx), for example, is required for specifying the identity of the third thoracic (T3) segment of the adult, which includes the dorsal haltere, an appendage required for flight, and the ventral T3 leg. Ubx mutants show homeotic transformations of the T3 leg towards the identity of the T2 leg and the haltere towards the wing. All Hox genes, including Ubx, encode homeodomain containing transcription factors, raising the question of what target genes Ubx regulates to generate these adult structures. To address this question, we carried out whole genome ChIP-chip studies to identify all of the Ubx bound regions in the haltere an

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Matthew Slattery 

PROVIDER: E-GEOD-26793 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress