Identification and functional analysis of epigenetically silenced microRNAs in colorectal cancer cells

ABSTRACT: Abnormal miRNA expression has been linked to the development and progression of human cancers, and such dysregulation can result from aberrant DNA methylation. We combined the analysis of miRNA expression data deposited with empirical DNA methylation data in HCT116 and DKO colon cancer cells (SRA accession# SRP001414) to identify novel DNA methylation regulated miRNAs. ABSTRACT: Abnormal microRNA (miRNA) expression has been linked to the development and progression of several human cancers, and such dysregulation can result from aberrant DNA methylation. While a small number of miRNAs is known to be regulated by DNA methylation, we postulated that such epigenetic regulation is more prevalent. By combining MBD-isolated Genome Sequencing (MiGS) to evaluate genome-wide DNA methylation pat

ORGANISM(S): Homo sapiens

SUBMITTER: Angela Ting 

PROVIDER: E-GEOD-26819 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress