Liver effects of Aflatoxin B1 (AFB1) in wild type (C57BL/6J) and hepatitis C virus-transgenic (HCV-Tg) mice

ABSTRACT: Viral hepatitis and aflatoxin B1 (AFB1) exposure are common risk factors for hepatocellular carcinoma (HCC). The incidence of HCC in individuals co-exposed to hepatitis C (HCV) or B virus and AFB1 is greater than could be explained by the additive effect, yet the mechanisms are poorly understood due to lack of an animal model. This study investigated the outcomes and mechanisms of combined exposure to HCV and AFB1. We hypothesized that HCV transgenic (HCV-Tg; expressing core, E1, E2, and p7, nucleotides 342-2771) mice will be prone to hepatocarcinogenesis when exposed to AFB1. Neonatal (7 days old) HCV-Tg or C57BL/6J wild-type mice were exposed to AFB1 (6 ug/g bw) or tricaprylin vehicle (15 ul/g bw) and male offspring were followed for up to 12 months. No liver lesions were observed in veh

ORGANISM(S): Mus musculus

SUBMITTER: Ivan Rusyn 

PROVIDER: E-GEOD-26838 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress