Promotion of Lung Tumorigenesis By Beta-catenin

ABSTRACT: Although mutations in Kras are present in 21% of lung tumors, there is a high level of heterogeneity in phenotype and outcomes amongst lung cancer patients suggesting the importance of other pathways. Wnt/β-catenin signaling is a known oncogenic pathway that plays a well defined role in colon and skin cancer but its role in lung cancer remains unclear. We show that activation of Wnt/β-catenin in the bronchiolar epithelium of the adult lung does not promote tumor development by itself. However, activation of Wnt/β- catenin signaling leads to a dramatic increase in tumor formation both in overall tumor number and size compared to KrasG12D alone. We show that activation of Wnt/β- catenin signaling significantly alters the KrasG12D tumor phenotype resulting in a phenotypic switch from bronchio

ORGANISM(S): Mus musculus

SUBMITTER: Eugenia Pacheco-Pinedo 

PROVIDER: E-GEOD-26850 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress