Gene Expression Analysis of Dupuytren's Disease
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Andrew Zhang
PROVIDER: E-GEOD-2688 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression analysis of Dupuytren's disease: the role of TGF-beta2.
Zhang A Y AY Fong K D KD Pham H H Nacamuli R P RP Longaker M T MT Chang J J
The Journal of hand surgery, European volume 20080811 6
Dupuytren's disease is characterised by nodular fibroblastic proliferation of the palmar fascia leading to contracture of the hand. Transforming growth factor beta (TGF-beta) is thought to play a role in its pathogenesis. We performed a cDNA microarray analysis of Dupuytren's diseased cord tissue with an emphasis on TGF-beta isoforms. Normal-appearing transverse ligament of the palmar fascia from adjacent to the diseased cord and palmar fascia from patients undergoing carpal tunnel release were ...[more]
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