Bisphenol A Induced the Expression of DNA Repair Genes in Human Breast Epithelial Cells

ABSTRACT: Xenoestrogens are part of a group of agents termed endocrine disruptors because of their capacity to perturb normal hormonal actions.It has been suggested that xenoestrogens may contribute to the development of hormone-dependent cancers, such as breast and endometrial cancers. Bisphenol A (BPA) is polymerized to manufacture polycarbonate plastic and epoxy resins. Human exposure occurs when BPA leaches from plastic-lined food and beverage cans. In the present work we are aiming to determine if BPA has carcinogenic properties by using an in vitro system. For this purpose the human breast epithelial cells MCF-10F were treated with 10-3M to 10-9M BPA continuously for two weeks. The MCF-10F cells treated with 10-3M and 10-4M BPA died indicating that these concentrations were toxic for the human

ORGANISM(S): Homo sapiens

SUBMITTER: Yong Huang 

PROVIDER: E-GEOD-26884 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress