Comparative gene expression profile of Ngn3-overexpressing cultured hippocampal neurons vs the corresponding control populations

ABSTRACT: Gene expression profiles of Ngn3-overexpressing cultured hippocampal neurons was compared to the profile of the corresponding control populations. (neurons expressing GFP). Neurogenin3, a proneural transcription factor controlled by Notch receptor, is involved in hippocampal neuron differentiation and synapses, but little is known about the molecular bases of Ngn3 activity in neurons. Microarray analysis indicated that overexpression of Ngn3 upregulated a number of genes related with cytoskeleton dynamics. One of then was Fmn1 whose protein is associated with actin and microtubule cytoskeleton. Overexpression of the isoform Fmn1-Ib in cultured hippocampal neurons induced an increase in the number of primary dendrites and in the number of glutamatergic synaptic inputs without affecting GAB

ORGANISM(S): Mus musculus

SUBMITTER: Ana Dopazo 

PROVIDER: E-GEOD-26911 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress