Common neuroinflammatory pathways in neurodegenerative diseases

ABSTRACT: Neurodegenerative diseases of the central nervous system are characterised by pathogenetic cellular and molecular changes in specific areas of the brain that lead to the dysfunction and/or loss of explicit neuronal populations. Despite exhibiting different clinical profiles and selective neuronal loss, common features such as abnormal protein deposition, dysfunctional cellular transport, mitochondrial deficits, glutamate excitotoxicity and inflammation are observed in most, if not all, neurodegenerative disorders, suggesting converging pathways of neurodegeneration. We have generated comparative genome-wide gene expression data for Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, multiple sclerosis, Parkinson’s disease and schizophrenia using an extensive cohort of

ORGANISM(S): Homo sapiens

SUBMITTER: Pascal Durrenberger 

PROVIDER: E-GEOD-26927 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress