Discovery of Shear- and Side-specific mRNAs and miRNAs in Human Aortic Valvular Endothelial Cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hanjoong Jo
PROVIDER: E-GEOD-26953 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells.
Holliday Casey J CJ Ankeny Randall F RF Jo Hanjoong H Nerem Robert M RM
American journal of physiology. Heart and circulatory physiology 20110624 3
The role of endothelial cells (ECs) in aortic valve (AV) disease remains relatively unknown; however, disease preferentially occurs in the fibrosa. We hypothesized oscillatory shear (OS) present on the fibrosa stimulates ECs to modify mRNAs and microRNAs (miRNAs) inducing disease. Our goal was to identify mRNAs and miRNAs differentially regulated by OS and laminar shear (LS) in human AVECs (HAVECs) from the fibrosa (fHAVECs) and ventricularis (vHAVECs). HAVECs expressed EC markers as well as som ...[more]
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