Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human hepatoblastoma cell lines to identify potential peroxisome proliferator-activated receptor (PPAR) target genes

ABSTRACT: HepG2 tet-off hPPARs treated with ligands

ORGANISM(S): Homo sapiens

SUBMITTER: Takahide Kohro 

PROVIDER: E-GEOD-2699 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms.

Tachibana Keisuke K   Kobayashi Yumi Y   Tanaka Toshiya T   Tagami Masayuki M   Sugiyama Akira A   Katayama Tatsuya T   Ueda Chihiro C   Yamasaki Daisuke D   Ishimoto Kenji K   Sumitomo Mikako M   Uchiyama Yasutoshi Y   Kohro Takahide T   Sakai Juro J   Hamakubo Takao T   Kodama Tatsuhiko T   Doi Takefumi T  

Nuclear receptor 20051003

<h4>Background</h4>Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and commonly play an important role in the regulation of lipid homeostasis. To identify human PPARs-responsive genes, we established tetracycline-regulated human hepatoblastoma cell lines that can be induced to express each human PPAR and investigated the gene expression profiles of these cells.<h4>Results</h4>The expression of each introduced PPAR gene was investigated using the var  ...[more]

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