Expression data from severe asthmatics, mild asthmatics and healthy controls

ABSTRACT: Background: Around 5% of children with asthma suffer from chronic symptoms and/or severe exacerbations despite extensive treatment. The causes of severe therapy-resistant childhood asthma are poorly understood. Objectives: To define global patterns of gene expression in severe therapy-resistant vs. controlled asthma and healthy controls. Methods: Children with severe, therapy-resistant (SA, n=20) and controlled asthma (CA, n=20) were identified from a Swedish nation-wide study including extensive clinical and immunological characterisation. In addition, healthy controls were recruited (Ctrl, n=19). White blood cells were isolated and the global transcriptome profile was characterised using the Affymetrix Human Gene ST 1.0 chip. Results: 1378 genes were differentially expressed in one or se

ORGANISM(S): Homo sapiens

SUBMITTER: Christina Orsmark Pietras 

PROVIDER: E-GEOD-27011 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress