Role of transcriptional regulators IFRD1 and IFRD2 in intestinal lipid absorption and obesity

ABSTRACT: Because of the epidemic rise of obesity worldwide, the identification of novel target genes for pharmacological treatment of obesity and related disorders is becoming of high importance. IFRD1 and IFRD2 are members of a novel transcriptional regulators family. Intestinal over-expression of mouse homologue of IFRD1 promoted intestinal triglyceride uptake and induced whole body adiposity in mice. To further elucidate the role of IFRD1 and IFRD2 in vivo, we generated mice lacking both mouse homologues of IFRD1 (TIS7) and IFRD2 (SKMc15) genes. Here, we report that mice deficient in TIS7 and SKMc15 genes, despite normal calorie intake had severely reduced amount of adipose tissue, were resistant to diet-induced obesity and displayed high glucose tolerance. Lower dietary fat entry into the cir

ORGANISM(S): Mus musculus

SUBMITTER: Johannes Rainer 

PROVIDER: E-GEOD-27019 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress