Transcription profiling of Macaca mulatta adrenal gland over a 24 hour period to investigate circadian regulation of gene expression

ABSTRACT: Circadian regulation of gene expression in central and peripheral tissue has been studied in mice. The biomedical implications of this findings led us to the development of a model in which to study the circadian mechanisms underlying primate physiology. The objective of this experiment has been to identify genes that are circadianly regulated in the monkey (macaca mulatta) adrenal gland. We analyzed the data using three filters: the first one for presence in at least three out of six time points (presence call=P, P value<0.05). The second one for high amplitude oscillations, using the coefficient of variation with a cutt of value of 0.2 (selecting probesets above that value). The last one for circadian expression, calculating the correlation of each curve to cosine curves of 24h periodici

ORGANISM(S): Macaca mulatta

SUBMITTER: Dario Lemos 

PROVIDER: E-GEOD-2703 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress