Transcription profiling by array of human peripheral blood mononuclear cells from patients with peripheral arterial disease

ABSTRACT: Peripheral arterial disease (PAD) is a relatively common manifestation of systemic atherosclerosis that leads to progressive narrowing of the lumen of leg arteries. Circulating monocytes are in contact with the arterial wall and can serve as reporters of vascular pathology in the setting of PAD. We performed gene expression analysis of peripheral blood mononuclear cells (PBMC) in patients with PAD and controls without PAD to identify differentially regulated genes. We identified 87 genes differentially expressed in the setting of PAD; 40 genes were upregulated and 47 genes were downregulated. We employed an integrated bioinformatics pipeline coupled with literature curation to characterize the functional coherence of differentially regulated genes. Notably, upregulated genes mediate immune

ORGANISM(S): Homo sapiens

SUBMITTER: Iftikhar Kullo 

PROVIDER: E-GEOD-27034 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress