Dermatan sulfate is involved in the tumorigenic properties of Esophagus Squamous Cell Carcinoma

ABSTRACT: Extracellular matrix, either produced by cancer cells or by cancer-associated fibroblasts, influences angiogenesis, invasion and metastasis. Chondroitin/dermatan sulfate (CS/DS) proteoglycans, which occur both in the matrix and at the cell surface, play important roles in these processes. The unique feature that distinguishes DS from CS is the presence of iduronic acid (IdoA) in DS. The main IdoA-producing enzyme, DS epimerase 1 (DS-epi1) was highly up-regulated in ESCC biopsies. To further understand the roles of IdoA in tumor development, DS-epi1 expression, and consequently IdoA content, was downregulated in ESCC cells. IdoA-deficient cells exhibited decreased migration and invasion capabilities in vitro, which was associated with reduced cellular binding of hepatocyte growth factor, i

ORGANISM(S): Homo sapiens

SUBMITTER: Anna Ekstrand 

PROVIDER: E-GEOD-27040 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress