Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identification of Hundreds of Conserved and Non-conserved Human MicroRNAs

ABSTRACT: Determining the expression of known and computationally predicted microRNAs by microRNA microarray in several tissues (placenta, testis, thymus, brain and prostate) Keywords: parallel sample microRNAs expression profile

ORGANISM(S): Homo sapiens

SUBMITTER: Eilon Sharon

PROVIDER: E-GEOD-2708 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Identification of hundreds of conserved and nonconserved human microRNAs.

Bentwich Isaac I Avniel Amir A Karov Yael Y Aharonov Ranit R Gilad Shlomit S Barad Omer O Barzilai Adi A Einat Paz P Einav Uri U Meiri Eti E Sharon Eilon E Spector Yael Y Bentwich Zvi Z

Nature genetics 20050619 7

MicroRNAs are noncoding RNAs of approximately 22 nucleotides that suppress translation of target genes by binding to their mRNA and thus have a central role in gene regulation in health and disease. To date, 222 human microRNAs have been identified, 86 by random cloning and sequencing, 43 by computational approaches and the rest as putative microRNAs homologous to microRNAs in other species. To prove our hypothesis that the total number of microRNAs may be much larger and that several have emerg ...[more]

PMID: 15965474

Similar Datasets

Identification of Hundreds of Conserved and Non-conserved Human MicroRNAs

Project description:Determining the expression of known and computationally predicted microRNAs by microRNA microarray in several tissues (placenta, testis, thymus, brain and prostate) Keywords: parallel sample

2005-06-19 | GSE2708 | GEO

Transgenic overexpression of Pla2g10

Project description:Microarray gene profiling of thymus from PLA2G10-Tg mice in comparison with that from control mice. Pla2g10-Tg/+ mice and littermate controls (C57BL/6 background); 6-months old; thymus; pooled from 4 mice for each genotype.

2016-01-29 | E-GEOD-77336 | biostudies-arrayexpress

Computational evidence for hundreds of non-conserved plant microRNAs.

Project description: Not available

| S-EPMC1249568 | biostudies-literature

Identification of target genes of tumor suppressor microRNAs in human cancer

Project description:To identify target genes of tumor suppressive microRNAs in human cancer, several cell lines (bladder cancer, prostate cancer, renal cell carcinoma, and head and neck squamous cell carcinoma) were subjected to Agilent whole genome microarrays. miR-517a, miR-218, miR-145, miR-1 and miR-874 function as tumor suppressors. Human cancer cell lines (BOY, T24, A498, PC3, DU145, FaDu, SAS, HSC3, IMC3) were transfected with miRNAs (miR-517a, miR-218, miR-145, miR-1, miR-874). The miRNA-transfected human cancer cell lines were compared to control cell lines.

2012-02-09 | E-GEOD-24782 | biostudies-arrayexpress

Hundreds of conserved non-coding genomic regions are independently lost in mammals.

Project description: Not available

| S-EPMC3526296 | biostudies-literature

A novel hybrid kinase is essential for regulating the ÏB-mediated stress response of Bacillus cereus.

Project description:A common bacterial strategy for monitoring environmental challenges is to use two-component systems, which consist of a sensor histidine kinase (HK) and a response regulator (RR). In the food-borne pathogen Bacillus cereus, the alternative sigma factor ÏB is activated by the RR RsbY. Here we present strong indications that the PP2C-type phosphatase RsbY receives its input from the multi-sensor hybrid kinase BC1008 (renamed RsbK). Genome analyses revealed that, across bacilli, rsbY and rsbK are located in a conserved gene cluster. A B. cereus rsbK deletion strain was shown to be incapable of inducing ÏB upon stress conditions and was impaired in its heat adaptive response. Comparison of the wild-type and rsbK mutant transcriptomes upon heat shock revealed that RsbK was primarily involved in the activation of the ÏB-mediated stress response. Truncation of the RsbK RR receiver domain demonstrated the importance of this domain for ÏB induction upon stress. The domain architecture of RsbK suggests that in the B. cereus group and in other bacilli, environmental and intracellular stress signalling routes are combined into one single protein. This strategy is markedly different from the ÏB activation pathway in other low-GC Grampositives. Two different comparisons were performed (both in duplo and Cy5-Cy3 dye-swapped): (1) B. cereus WT 30Â°C versus B. cereus WT 42Â°C (10 min heat shock) (2) B. cereus WT 42Â°C versus B. cereus FM1404 42Â°C Data from comparisons (2) were subsequently compared with transcriptome data obtained previously by Van Schaik et al., 2007

2010-06-24 | E-GEOD-14589 | biostudies-arrayexpress

Systematic profiling of human microRNAs in plasma from nasopharyngeal carcinoma patients reveals candidate biomarkers

Project description:We used microarrays to perform systematic profiling of human microRNAs in plasma from nasopharyngeal carcinoma (NPC) patients to find potential biomarkers. By comparing the plasma microRNA profiles of the NPC patients and healthy donors, potential biomarkers for NPC were investigated. A total of 39 microRNAs were aberrantly expressed based on 50 Agilent microarrays containing 887 human microRNAs 50 microarrays containing 887 human microRNAs were used to screen for potential biomarkers with significant differential expression levels between 31 NPC patients and 19 healthy donors.

2013-08-01 | E-GEOD-43329 | biostudies-arrayexpress

Identification of target genes of cancer-related microRNAs in human cancer

Project description:To identify target genes of oncogenic or tumor suppressive microRNAs in human cancer, several cell lines (bladder cancer, prostate cancer, renal cell carcinoma. lung squamous cell carcinoma and head and neck squamous cell carcinoma) were subject to Agilent whole genome microarray. miR-183 and miR-96 function as oncogene. miR-1, miR-133a, miR-135a, miR-145 and miR-375 function as tumor suppressor The miRNA transfected human cancer cell lines (KK47, T24, A498, PC3, DU145, FaDu, SAS, PC10 and H157) were compared to control cell lines.

2012-02-09 | E-GEOD-26032 | biostudies-arrayexpress

Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA

Project description:This SuperSeries is composed of the following subset Series: GSE18834: Human Argonaute Immunoaffinity Purification-associated RNA. GSE18835: mRNA abundance in HEK293T cells mock or miR-124 transfected. GSE18836: Translation Profiling +/- miR-124. GSE18837: Unamplified mRNA abundance in miR-124 and mock-transfected cells. Refer to individual Series

2009-11-09 | E-GEOD-18889 | biostudies-arrayexpress

Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines Panc-1, FaDu and PC3

Project description:To identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, hypopharyngeal squamous cell carcinoma and prostate cancer) were subjected to Agilent whole genome microarrays. Human cell lines (Panc-1, FaDu and PC3) were treated with miRNAs (miR99a-5p, miR-99a-3p, miR-100-3p, miR-150-5p and miR-150-3p), siRNAs (si-FOXQ1).

2016-08-16 | E-GEOD-85614 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data