Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Maria Navarro
PROVIDER: E-GEOD-27092 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature immunology 20110313 4
Here we report an unbiased analysis of the cytotoxic T lymphocyte (CTL) serine-threonine phosphoproteome by high-resolution mass spectrometry. We identified approximately 2,000 phosphorylations in CTLs, of which approximately 450 were controlled by T cell antigen receptor (TCR) signaling. A significantly overrepresented group of molecules identified included transcription activators, corepressors and chromatin regulators. A focus on chromatin regulators showed that CTLs had high expression of th ...[more]