Genomic Signatures of Metastasis in Prostate Cancer

ABSTRACT: Background: Metastases result in 90% of all cancer deaths. Prostate cancer primary tumors evolve to become metastatic through selective alterations, such as amplification and deletion of genomic DNA. Methods: Genomic DNA copy number alterations were used to develop a gene signature that measured the metastatic potential of a prostate cancer primary tumor. We studied the genomic landscape of these alterations in 294 primary tumors and 49 metastases from 5 independent cohorts. Receiver-operating characteristic cross-validation and Kaplan-Meier survival analysis were performed to assess the accuracy of our predictive model. The signature was measured in a panel of 337 cancer cell lines from 29 different tissue origins. Results: We identified 399 copy number alterations around ge

ORGANISM(S): Homo sapiens

SUBMITTER: Alex Pearlman 

PROVIDER: E-GEOD-27105 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress