Gene expression and pathway analyses following lycopene and fish oil supplementation in men with low-risk prostate cancer

ABSTRACT: Animal and epidemiological studies suggest that lycopene and fish oil may modify the risk or delay progression of prostate cancer, however, the molecular mechanisms involved are poorly understood. We examined the effects of these micronutrients on prostate gene expression in a double-blind placebo-controlled randomized clinical trial (Molecular Effects of Nutritional Supplements, MENS). Eighty-four men with low risk prostate cancer were stratified based on self-reported dietary consumption of fish and tomatoes and then randomly assigned to a 3-month intervention of lycopene (intervention B; n = 29) or fish oil (intervention C; n = 27) supplementation or placebo (intervention A; n = 28). Gene expression in morphologically normal prostate tissue was studied at baseline and at 3 months via cD

ORGANISM(S): Homo sapiens

SUBMITTER: Mark Magbanua 

PROVIDER: E-GEOD-27140 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress