Correlates of chronic stress and their influence on the development of substance use in a population-based cohort of young adults (OYSUP)

ABSTRACT: Background: We seek to understand correlates of chronic stress and their influence on the development of substance use in a population-based cohort of young adults (OYSUP). Methodology: We evaluated clinical features, salivary RNA metrics and differential expression of candidate genes in unfractionated saliva samples from 48 individuals (31% female, 55% ever-smoking) randomly selected from two groups stratified by high versus low severe negative life events and difficulties within the last year as as measured by the Life Events and Difficulties Schedule (LEDS, Brown & Harris, 1978). We used multiple analytical platforms, multiple reference genes and 18 replicates of all gene expression assays (assays). We chose 38 candidate genes previously identified as differentially expressed in a geno

ORGANISM(S): Homo sapiens

SUBMITTER: Denise Nishita 

PROVIDER: E-GEOD-27144 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress