A profibrotic gene expression program induced by Egr-1 in skin fibroblasts

ABSTRACT: Systemic sclerosis (SSc) is characterized by vascular damage, autoimmunity and fibrosis and is associated with highly variable clinical presentation and disease course. Aberrant transforming growth factor-ß (TGF-ß) signaling via the early immediate transcription factor Egr-1 is implicated in the pathogenesis of SSc. To shed light on the role of Egr-1 in fibrosis, regulation of gene expression in human skin fibroblasts overexpressing Egr-1 was examined by genome-wide expression analysis. Over 600 genes were found to be regulated by Egr-1. The Egr-1-responsive gene signature is largely comprised of genes involved in cell proliferation, TGF-ß signaling, wound healing, extracellular matrix synthesis and vascular development. Expression of the Egr-1 responsive genes was evaluated in a microarr

ORGANISM(S): Homo sapiens

SUBMITTER: Swati Bhattacharyya 

PROVIDER: E-GEOD-27165 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress