Chronic exposure to ambient particulate matter alters cardiac gene expression patterns and markers of oxidative stress in rats

ABSTRACT: Exposure to ambient particulate matter (PM) significantly increases cardiovascular morbidity and mortality in the general population. We hypothesized that some components of PM can affect the gene expression patterns in the hearts of rats exposed for 3 months to filtered air (FA), coarse (CP; 2.5 < dp < 10 μm), fine (FP; dp ≤ 2.5 μm) or ultrafine (UFP; dp ≤ 0.18 μm) components of PM. The median diameters of CP, FP, and UFP were 3 μm, 0.7 μm and 0.07 μm, respectively. Exposures (n = 8 per group) were performed using a particle concentrator system in Riverside, California, an area with high ambient levels of photochemically derived gaseous and particulate pollutants. At the end of the exposure, hearts were subjected to gene expression profiling by using Illumina RatRef-12 bead chips and leve

ORGANISM(S): Rattus norvegicus

SUBMITTER: Boris Simkhovich 

PROVIDER: E-GEOD-27179 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress