Transcription profiling of acute monocytic leukemia (AML-M5) patients with DNMT3A mutations

ABSTRACT: To understand the pathogenesis of DNMT3A in acute monocytic leukemia (AML-M5), we identified genes that are expressed differently in leukemia cells from AML-M5 patients collected at diagnosis with DNMT3A mutations (6 cases) compared to those without the mutations (4 cases). Differences of expression level were observed in 889 out of 20,723 (4.3%) annotated genes by using Affymetrix microarray with 469 genes upregulated and 420 genes downregulated. Leukemia cells in bone marrow of acute monocytic leukemia patients were collected at diagnosis for RNA extraction and hybridization on Affymetrix microarrays. 6 cases of AML-M5 samples with DNMT3A mutations and 4 cases of AML-M5 samples wihtout DNMT3A mutations were used.

ORGANISM(S): Homo sapiens

SUBMITTER: Zhaohui Gu 

PROVIDER: E-GEOD-27187 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress