Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Donor cell type influences the epigenome and differentiation potential of human induced pluripotent stem cells

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE27134: DNA methylation data from human iPS cells, ES cells, cord blood, and keratinocytes GSE27186: Expression data of human somatic cell types and induced pluripotent stem cells GSE31742: DNA methylation data from human keratinocyte-derived iPS cells (N9) and ES cells Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Patrick Cahan 

PROVIDER: E-GEOD-27224 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells.

Kim Kitai K   Zhao Rui R   Doi Akiko A   Ng Kitwa K   Unternaehrer Juli J   Cahan Patrick P   Huo Hongguang H   Loh Yuin-Han YH   Aryee Martin J MJ   Lensch M William MW   Li Hu H   Collins James J JJ   Feinberg Andrew P AP   Daley George Q GQ  

Nature biotechnology 20111127 12

We compared bona fide human induced pluripotent stem cells (iPSCs) derived from umbilical cord blood (CB) cells and neonatal keratinocytes (K). As a consequence of both incomplete erasure of tissue-specific methylation and aberrant de novo methylation, CB-iPSCs and K-iPSCs were distinct in genome-wide DNA methylation profiles and differentiation potential. Extended passage of some iPSC clones in culture did not improve their epigenetic resemblance to embryonic stem cells, implying that some huma  ...[more]

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