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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Impact of cellular miRNAs on the biomarker signatures of circulating miRNAs

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE27230: Analysis of the impact of cellular miRNA signatures on the profiles of circulating miRNA biomarkers (fractionation data) GSE27253: Analysis of the impact of cellular miRNA signatures on the profiles of circulating miRNA biomarkers (variability data) Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Radha Duttagupta

PROVIDER: E-GEOD-27256 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Impact of cellular miRNAs on circulating miRNA biomarker signatures.

Duttagupta Radha R Jiang Rong R Gollub Jeremy J Getts Robert C RC Jones Keith W KW

PloS one 20110617 6

Effective diagnosis and surveillance of complex multi-factorial disorders such as cancer can be improved by screening of easily accessible biomarkers. Highly stable cell free Circulating Nucleic Acids (CNA) present as both RNA and DNA species have been discovered in the blood and plasma of humans. Correlations between tumor-associated genomic/epigenetic/transcriptional changes and alterations in CNA levels are strong predictors of the utility of this biomarker class as promising clinical indicat ...[more]

PMID: 21698099

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