An antibody to Streptococcus pneumoniae capsular polysaccharide enhances quorum sensing

ABSTRACT: The primary mechanism by which pneumococcal capsular polysaccharide-based vaccines are believed to mediate protection is by induction of serotype-specific opsonic antibodies that facilitate bacterial killing by phagocytes (opsonophagocytosis). However, antibodies that are protective against experimental pneumococcal pneumonia in mice but do not promote opsonophagocytic killing in vitro have also been identified 1-3. Such non-opsonic antibodies are associated with bacterial clearance in vivo, but the mechanism by which this occurs is unknown. In this letter, we demonstrate that a protective, non-opsonic serotype 3 pneumococcal capsular polysaccharide-specific monoclonal antibody (MAb) enhances quorum sensing, which results in competence induction and fratricide of serotype 3 pneumococcus

ORGANISM(S): Streptococcus pneumoniae

SUBMITTER: Masahide Yano 

PROVIDER: E-GEOD-27258 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress