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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiling of Non-small cell lung cancer in Taiwan

ABSTRACT: This study focus on the expression signature between tumor and adjacent normal tissues. Tumor(T) and adjacent normal(N) tissue pairs from 25 stage I lung adenocarcinoma patients were selected for RNA extraction and hybridization on microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Yih-Jyh Shann

PROVIDER: E-GEOD-27262 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade.

Wei Tong-You W TY Juan Chi-Chang CC Hisa Jiun-Yi JY Su Li-Jen LJ Lee Yuan-Chii G YC Chou Hsiang-Yun HY Chen Jo-Mei M JM Wu Yu-Chung YC Chiu Shao-Chih SC Hsu Chung-Ping CP Liu Kuo-Lin KL Yu Chang-Tze R CT

Cancer science 20120808 9

Increasing evidence suggests that PRMT5, a protein arginine methyltransferase, is involved in tumorigenesis. However, no systematic research has demonstrated the cell-transforming activity of PRMT5. We investigated the involvement of PRMT5 in tumor formation. First, we showed that PRMT5 was associated with many human cancers, through statistical analysis of microarray data in the NCBI GEO database. Overexpression of ectopic PRMT5 per se or its specific shRNA enhanced or reduced cell growth under ...[more]

PMID: 22726390

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