Transcription profiling of human affected and unaffected skin of 4 psoriatic patients and normal skin of 3 psoriasis free individuals to reveal a complex regulation of molecular stress and immune gene responses

ABSTRACT: Gene expression profiling was performed on biopsies of affected and unaffected psoriatic skin and normal skin from seven Japanese patients to obtain insights into the pathways that control this disease. U95A Affymetrix DNA chips that contain oligonucleotide arrays of approximately 12,000 well-characterized human genes were used in the study. The statistical analysis of the Affymetrix data, based on the ranking of the Student-test statistic, revealed a complex regulation of molecular stress and immune gene responses. The majority of the 266 induced-genes in affected and unaffected psoriatic skin were involved with interferon mediation, immunity, cell-adhesion, cytoskeleton restructuring, protein trafficking and degradation, RNA regulation and degradation, signaling transduction, apoptosis a

ORGANISM(S): Homo sapiens

DISEASE(S): psoriasis vulgaris

SUBMITTER: William Kenworthy 

PROVIDER: E-GEOD-2737 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress