Expression data from zinc-finger-transcription-factor-induced Fulvestrant-Resistant MCF7 Cell Lines

ABSTRACT: Multiple gene expression studies have demonstrated that breast cancer biological diversity is associated with distinct transcriptional programs. Transcription factors, because of their unique ability to coordinate the expression of multiple genes, are speculated to play a role in generating phenotypic plasticity associated with cancer progression including acquired drug resistance. Combinatorial libraries of artificial zinc-finger transcription factors (ZF-TFs) provide a robust means for inducing and understanding various functional components of the cancer phenotype. Herein, we utilized combinatorial ZF-TF library technology to better understand how breast cancer cells acquire resistance to a fulvestrant, a clinically important anti-endocrine therapeutic agent. We isolated six ZF-TF li

ORGANISM(S): Homo sapiens

SUBMITTER: Ben Wittner 

PROVIDER: E-GEOD-27444 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress