A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways

ABSTRACT: The mitochondrial and nuclear genomes contribute to mitochondrial function, and when mitochondrial function is compromised, mitochondrial retrograde signaling alters nuclear gene expression. We performed gene expression profiling of engineered cells that had mitochondria containing a disease-associated mutation that causes mitochondrial dysfunction. By generating networks of transcription factors that targeted these genes, the authors revealed putative mitochondrial retrograde signaling pathways. One such pathway involved retinoic acid receptor alpha (RXRA), the mRNA for which was reduced in the mutant cells. Network analysis and experiments in cells suggested that mitochondrial dysfunction caused by the mutation initiated a positive feedback loop that aggravated mitochondrial dysfunction:

ORGANISM(S): Homo sapiens

SUBMITTER: Sehyun Chae 

PROVIDER: E-GEOD-27545 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress