Integrating Factor Analysis and a Transgenic Mouse Model to Reveal a Peripheral Blood Predictor of Breast Tumors
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Erich Huang
PROVIDER: E-GEOD-27567 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Integrating factor analysis and a transgenic mouse model to reveal a peripheral blood predictor of breast tumors.
LaBreche Heather G HG Nevins Joseph R JR Huang Erich E
BMC medical genomics 20110722
<h4>Background</h4>Transgenic mouse tumor models have the advantage of facilitating controlled in vivo oncogenic perturbations in a common genetic background. This provides an idealized context for generating transcriptome-based diagnostic models while minimizing the inherent noisiness of high-throughput technologies. However, the question remains whether models developed in such a setting are suitable prototypes for useful human diagnostics. We show that latent factor modeling of the peripheral ...[more]
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