Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Profile of small RNA transcriptome during cortical development in the Rat

ABSTRACT: Small non-coding RNAs play important roles in regulating gene expression during development and disease. However, a comprehensive analysis of small RNAs in developing brain is largely lacking. By using next-generation sequencing technique, we carried out a systematic analysis of small RNA transcriptome of rat neocortex from early developmental stage till adult. Our results revealed an extraordinary degree of stage-specific profiling of miRNA, and other classes of small RNAs including snoRNA, rasRNA, scRNA and unexpectedly piRNA, which was considered to be solely expressed in germline tissues. Developmentally regulated miRNA editing was also observed. This study further showed the effectiveness of the high through-put sequencing in genome-wide analysis of small RNAs. The dataset described here will greatly contribute to our understanding of the divergence, variation, and function of small RNAs and may be a valuable resource in clarifying new regulatory mechanisms of cortical development. Identification and quantification of small RNA: forebrain and cortex from E10 to P28

ORGANISM(S): Rattus norvegicus

SUBMITTER: Maojin Yao

PROVIDER: E-GEOD-27576 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptome analysis of microRNAs in developing cerebral cortex of rat.

Yao Mao-Jin MJ Chen Gang G Zhao Ping-Ping PP Lu Ming-Hua MH Jian Jiang J Liu Mo-Fang MF Yuan Xiao-Bing XB

BMC genomics 20120612

<h4>Background</h4>The morphogenesis of the cerebral cortex depends on the precise control of gene expression during development. Small non-coding RNAs, including microRNAs and other groups of small RNAs, play profound roles in various physiological and pathological processes via their regulation of gene expression. A systematic analysis of the expression profile of small non-coding RNAs in developing cortical tissues is important for clarifying the gene regulation networks mediating key develop ...[more]

PMID: 22691069

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Dataset Information

Profile of small RNA transcriptome during cortical development in the Rat

Publications

Transcriptome analysis of microRNAs in developing cerebral cortex of rat.

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