Developmental gene expression differences between neonatal and adult mouse atria and ventricles

ABSTRACT: We study the role of glycosylation in ion channel function. Specfically, we are focusing on how ion channel glycosylation modulates, controls, and impacts cardiac, skeletal muscle, and neuronal electrical activity. We wish to determine differences in gene expression through development and between the atria and ventricles of the mouse heart. Our data indicate differential sialylation directly affects voltage-gated sodium channel function through the developing heart in a chamber-specific manner. We wish to expand our findings to include other ion channels involved in the cardiac action potential, and to eventually create a map of the cardiac conduction system that details the role of differential glycosylation in cardiac excitability. Determining differential expression of the genes that r

ORGANISM(S): Mus musculus

SUBMITTER: Steven Head 

PROVIDER: E-GEOD-27589 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress