Dose dependent response of liver gene expression and lipoperoxidation to dietary long chain omega 3 PUFA

ABSTRACT: The cardioprotective effects of long chain (LC) 3PUFA can be achieved at the gene expression level, notably in liver. However, the complexity of biological pathways modulations and the nature of the bioactive molecules are still under investigation. The present study aimed to investigate the dose-response effects of LC 3PUFA on the production of peroxidated metabolites and on global gene expression in liver. The intake of LC ?3PUFA increased, in a dose-dependent manner, their incorporation in liver phospholipids but also the hepatic production of 4-HHE. Pathways related to inflammation were dose-dependently associated with the 3 groups but Group 2 was rather associated with inflammatory effects while Group 3 was anti-inflammatory. LC ?3PUFA had no effect on PPAR-controlled genes. However,

ORGANISM(S): Oryctolagus cuniculus

SUBMITTER: Alan McCulloch 

PROVIDER: E-GEOD-27621 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress