Hepatic gene expression changes in aging and R-?-lipoic acid supplementation: Necroinflammatory phenotype, lipid synthesis regulation and circadian rhythms.

ABSTRACT: To determine the effects of age and lipoic acid supplementation on hepatic gene expression, we fed young (3 months) and old (24 months) male Fischer 344 rats a diet with or without 0.2% (w/w) R-?-lipoic acid (LA) for two weeks. Total RNA isolated from liver tissue was analyzed by Affymetrix microarray to examine changes in transcriptional profile. Results showed an increase in pro-inflammatory gene expression in the aging liver, with increased immune cell function and tissue remodeling genes, representing 45% of the age-related transcriptome changes. Increased inflammation was corroborated by increases in soluble ICAM1 levels with age. There were also observed age-related increases in transcription of genes related to lipid and cholesterol synthesis including Acetyl CoA Carboxylase (Acacb

ORGANISM(S): Rattus norvegicus

SUBMITTER: Tory Hagen 

PROVIDER: E-GEOD-27625 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress