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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiles of spontaneous gastric tumors in the antrum of the stomach of 30,60, and 90 day old CEA424-SV40 -T antigen transgenic mice.

ABSTRACT: Analysis of global gene expression in the antral portion of the stomach in control and mice with a developing tumor to get further insight into the exact tumor type and the influence of local gene expression. Total RNA obtained from tissue samples from the antrum. Follow up of gene expression over the time of the tumor development

ORGANISM(S): Mus musculus

SUBMITTER: Joachim Schultze

PROVIDER: E-GEOD-27711 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen.

Ihler Fritz F Vetter Elena Viviana EV Pan Jie J Kammerer Robert R Debey-Pascher Svenja S Schultze Joachim L JL Zimmermann Wolfgang W Enders Georg G

PloS one 20120113 1

<h4>Background</h4>A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg) exhibits a neuroendocrine phenotype. It is unclear whether SV40 TAg induces the neuroendocrine phenotype by preferential transformation of progenitor cells committed to the neuroendocrine lineage or by transcriptional activation of neuroendocrine genes.<h4>Methodology/principal findings</h4>To address this question we analyzed CEA424-SV40 TAg-transgenic mice that develop spont ...[more]

PMID: 22253802

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2012-08-01 | E-GEOD-27712 | biostudies-arrayexpress

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