MiR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis

ABSTRACT: To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that microRNAs can promote the evolution of malignant behaviors by regulating multiple targets simultaneously. We performed a microRNA analysis of human melanoma, an aggressively invasive cancer, and found that miR-30b/30d upregulation correlates with stage, metastatic potential of primary tumors, shorter time to recurrence and reduced overall survival. Ectopic expression of miR-30b/30d promoted the metastatic behavior of melanoma cells by directly targeting the GalNAc transferase GALNT7, resulted in increased synthesis of the immunosuppressive cytokine IL-10, and reduced immune cell activation and recruitment. These data point to a key rol

ORGANISM(S): Homo sapiens

SUBMITTER: Jiri Zavadil 

PROVIDER: E-GEOD-27718 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress