Syntenin-1 is expressed in uveal melanoma and correlates with metastatic progression

ABSTRACT: Uveal melanoma is an aggressive cancer that metastasizes to the liver in about half of patients, being at that time almost always fatal. Identification of patients at high risk of metastases may provide indication for a frequent follow-up for early detection of metastases and treatment. The analysis of the gene expression profiling of primary human uveal melanomas showed high expression of SDCBP (encoding for syndecan-binding protein-1 or syntenin-1), which appeared higher in patients with recurrence, whereas expression of syndecans was lower and unrelated to progression. Moreover, we found that high expression of SDCBP gene was related to metastatic progression in two additional independent dataset of uveal melanoma patients. More importantly, immunohistochemistry showed that high expre

ORGANISM(S): Homo sapiens

SUBMITTER: Valentina Mirisola 

PROVIDER: E-GEOD-27831 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress