Gene expression of expanded and non-expanded natural killer cells from healthy donor and myeloma patients

ABSTRACT: Natural Killer cells (NK), a major constituent of innate immune system, have the ability to kill the transformed and infected cells without prior sensitization; can be put to immunotherapeutic use against various malignancies. NK cells discriminate between normal cells and transformed cells via a balance of inhibitory and activating signals induced by interactions between NK cell receptors and target cell ligands. Present study investigates whether expansion of NK cells could augment their anti-myeloma (MM) activity. For NK cell expansion, peripheral blood mononuclear cells from healthy donors and myeloma patients were co-cultured with irradiated K562 cells transfected with 4-1BBL and membrane-bound IL15 (K562-mb15-41BBL). A genome-wide profiling approach was performed to identify gene ex

ORGANISM(S): Homo sapiens

SUBMITTER: Tarun Garg 

PROVIDER: E-GEOD-27838 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress