Modulation of gene expression in heart and liver of hibernating black bears (Ursus americanus)

ABSTRACT: We analyzed gene expression in the American black bear, Ursus americanus, using a custom 12,800 cDNA probe (BA02) microarray to detect differences in expression that occur in heart and liver during winter hibernation in comparison to summer active animals. We identified 245 genes in heart and 319 genes in liver that were differentially expressed between winter and summer. The expression of 24 genes was significantly elevated during hibernation in both heart and liver. These genes are mostly involved in lipid catabolism and protein biosynthesis and include RNA binding protein motif 3 (Rbm3), which enhances protein synthesis at mildly hypothermic temperatures. Elevated expression of protein biosynthesis genes suggests induction of translation that may be related to adaptive mechanisms reduci

ORGANISM(S): Ursus americanus

SUBMITTER: Haifang Wang 

PROVIDER: E-GEOD-27875 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress