Development of gene expression signatures for latent and clinical tuberculosis (TB)

ABSTRACT: For further identify the differentiation between latent and clinical tuberculosis (TB), we employed whole genome microarray expression profiling to study genes with significant expression change in peripheral CD4+T cells between healthy control, latent tuberculosis (LTB) and clinical tuberculosis (TB). Our experiment included 4 groups: healthy donor (HD), latent TB1 (LTB1) with low IFN-gamma release level, latent TB2 (LTB2) with high IFN-gamma release level, and tuberculosis (TB) with high IFN-gamma release level. Human peripheral blood mononuclear cells were collected, from which CD4+T cells were isolated. Total RNA of each individuals of each group was extracted from peripheral CD4+T cells. One ?g of RNA mixture, pooled equivalently by each individual total RNA of each group, was adminis

ORGANISM(S): Homo sapiens

SUBMITTER: hyk liu 

PROVIDER: E-GEOD-27882 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress