Overexpression of NUCKS1 in colorectal cancer correlates with recurrence after curative surgery (copy number analysis)

ABSTRACT: Purpose: The purpose of this study is to identify a novel biomarker related with distant metastases of colorectal cancer (CRC). Experimental Design: We investigated mRNA expression profiles in 115 patients with CRC using an Affymetrix Gene Chip, and copy number profiles in 122 patients with CRC using an Affymetrix DNA Sty array. Genes in common between copy number and expression data were extracted as candidate genes. We analyzed the mRNA expression of candidate gene by quantitative reverse transcription polymerase chain reaction (RT-PCR) in 86 patients as a validation study. Furthermore, we analyzed the protein expression of candidate gene by immunohistochemical study in 269 patients, and investigated the relationship between protein expression and clinicopathologic features. Results: By

ORGANISM(S): Homo sapiens

SUBMITTER: Kaoru Mogushi 

PROVIDER: E-GEOD-27910 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress