Expression data from LNCap cell line treated with COP1 (RFWD2), ETV1, and JUN siRNAs

ABSTRACT: The proto-oncogenes ETV1, ETV4, and ETV5 encode members of the E26 transformation-specific (ETS) transcription factor family, which includes the most frequently rearranged and overexpressed genes in prostate cancer. Despite being critical regulators of development, little is known about their post-translational regulation. Here we identify the ubiquitin ligase COnstitutive Photomorphogenic-1 (COP1, also called RFWD2) as a tumor suppressor that negatively regulates ETV1, ETV4, and ETV5. ETV1, which is the member mutated more frequently in prostate cancer, was degraded after being ubiquitinated by COP1. Truncated ETV1 encoded by prostate cancer translocation TMPRSS2:ETV1 lacks the critical COP1 binding motifs (degrons) and was 50-fold more stable than wild-type ETV1. Almost all patient

ORGANISM(S): Homo sapiens

SUBMITTER: Jinfeng Liu 

PROVIDER: E-GEOD-27914 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress