Platelet microRNA-mRNA Co-Expression Profiles Correlate with Platelet Reactivity

ABSTRACT: MicroRNAs (miRNAs) regulate cell physiology by altering protein expression, but the biology of platelet miRNAs is largely unexplored. We tested whether platelet miRNA levels were associated with platelet reactivity by genome-wide profiling using platelet RNA from 19 healthy subjects. We found that human platelets express 284 miRNAs. Unsupervised hierarchical clustering of miRNA profiles resulted in 2 groups of subjects that appeared to cluster by platelet aggregation phenotypes. Seventy-four miRNAs were differentially expressed (DE) between subjects grouped according to platelet aggregation to epinephrine, a subset of which predicted the platelet reactivity response. Using whole genome mRNA expression data on these same subjects, we computationally generated a high-priority list of mi

ORGANISM(S): Homo sapiens

SUBMITTER: Leonard Edelstein 

PROVIDER: E-GEOD-27917 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress